对于复杂的疾病，大多数药物都非常无效，药物发现的成功率不断下降。虽然大多数基础和临床前研究的低质量、可重复性问题和转化无关性促成了这一点，但当前以器官为中心的医学和“一种疾病 - 一种目标 - 一种药物”的教条以最深刻的方式阻碍了创新。系统和网络医学及其治疗分支网络药理学彻底改变了宅男深夜性福导航定义、诊断、治疗以及理想情况下治愈疾病的方式。描述性疾病表型被因果性、多靶点信号模块定义的内型所取代，这些模块也解释了各自的合并症。通过协同的多化合物网络药理学和药物再利用，实现精确有效的治疗干预，
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Network pharmacology: curing causal mechanisms instead of treating symptoms
For complex diseases, most drugs are highly ineffective, and the success rate of drug discovery is in constant decline. While low quality, reproducibility issues, and translational irrelevance of most basic and preclinical research have contributed to this, the current organ-centricity of medicine and the ‘one disease–one target–one drug’ dogma obstruct innovation in the most profound manner. Systems and network medicine and their therapeutic arm, network pharmacology, revolutionize how we define, diagnose, treat, and, ideally, cure diseases. Descriptive disease phenotypes are replaced by endotypes defined by causal, multitarget signaling modules that also explain respective comorbidities. Precise and effective therapeutic intervention is achieved by synergistic multicompound network pharmacology and drug repurposing, obviating the need for drug discovery and speeding up clinical translation.
